Graduate student George Ongwae will present
"Innate Immune Response Modulation by Design Molecules"
on March 27, 2018 at 4:10 PM in Neville Hall, Room 3.
The innate immune system represents the first line of host-cell defense against an invading antigen. Immune responses depend on molecular patterns presented by pathogens. As an example, presence of N-formylmethionine, a conserved motif in bacterial proteins, activates leukocytes by binding to the human formyl peptide receptor leading to stimulation of phagocytosis. Similarly, the family of toll-like receptors (TLRs) sense viral and bacterial molecular patterns and trigger a cascade of events that end in upregulation of inflammatory cytokines. Innate responses are crucial to combating microbes but can also result in sever inflammatory disorders that are potentially life-threatening. Immune-response modulators are potential therapeutics that have shown promising early results in the various disease models.
In this seminar, a glimpse into innate-immune response modulation will be provided by way of three papers: (1) a study that identified a small molecule that binds to TLR8, thus, preventing its activation. Suppression of TLR8- mediated proinflammation was confirmed in cultured cells, (2) a report that described the dependency of immune activation on the clustering of TLRs. Clustering of TLRs was found to be mediated by synthetic dimers of ligands and lastly, (3) a study that used the N-formylmethionine motif to trigger an immune response against tumor cells in live mice, thus leading to tumor reduction.
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