Professor Yan Yu of Indiana University will present
"Spatially Organizing Biointerfaces to Interrogate Immune Functions"
on April 25, 2018 at 4:10 PM in Neville Hall, Room 3.
The immune system functions on the basis of intricately organized chemical reactions and physical forces. Examples range from the engulfment of invading bacteria that relies on a fine balance of competing mechanical forces, to the activation of Tlymphocytes that requires collective interactions between thousands of receptors at the junction between cells. Owing to the complexity of these processes, understanding immune functions using traditional biological tools is highly challenging. In this talk, I will present my group's research progress towards designing unique biointerfaces to enable the quantitative understanding an manipulation of immune functions. Our research so far has capitalized on Janus particles, which, like the two-faced Roman god Janus, are made chemically, biologically, optically or magnetically asymmetric. We developed Janus particle-based toolsets for measuring cell dynamics in multi-dimensions beyond translational motion and for spatiotemporally controlling cell functions. Using these methods, we uncovered new dynamics and mechanisms in immune processes, from phagocytosis to intracellular trafficking, which would otherwise be difficult to access with traditional means.