Kerney Jebrell Glover

Associate Professor
Graduate Advising Director
Advisor to Undergraduate Biochemistry Majors
Seeley G. Mudd, Room 612
(610) 758-5081

Research Interests:

Our broad interests lie in addressing the fundamental questions surrounding the interactions of lipid bilayers with proteins. Using various biophysical and biochemical techniques (e.g., NMR spectroscopy, analytical ultracentrifugation, fluorescence spectroscopy), we aim to understand the structure and function of proteins in the lipid milieu on a fundamental level.  Of particular interest to our research group is caveolin-1, a membrane protein that is pivotal in the formation of plasma membrane invaginations known as caveolae.

Teaching Interests:

Biochemistry and biophysical chemistry

Selected Publications:

Caldwell TA, Baoukina S, Brock AT, Oliver RC, Root KT, Krueger JK, Glover KJ, Tieleman DP, Columbus L. Low- q Bicelles Are Mixed Micelles.  J Phys Chem Lett. 2018, 2, 4469-4473.

Plucinsky SM, Root KT, Glover KJ. Efficient solubilization and purification of highly insoluble membrane proteins expressed as inclusion bodies using perfluorooctanoic acid. Protein Expr Purif. 2018, 143, 34-37.

Plucinsky SM, Glover KJ. The C-terminal domain of caveolin-1 and pulmonary arterial hypertension: An emerging relationship.  J Rae Dis Res Treat. 2017, 2, 44-48.

Mukai M, Glover KJ, Regen SL. Evidence for Surface Recognition by a Cholesterol-Recognition Peptide.  Biophys J. 2016, 110, 2577-2580.

Root KT, Glover KJ. Reconstitution and spectroscopic analysis of caveolin-1 residues 62-178 reveals that proline 110 governs its structure and solvent exposure.  Biochim Biophys Acta. 2016, 1858, 682-688.

Plucinsky SM, Glover KJ. Secondary Structure Analysis of a Functional Construct of Caveolin-1 Reveals a Long C-terminal Helix. Biophys J. 2015, 109, 1686-1688.

Root KT, Plucinsky SM, Glover KJ. Recent progress in the topology, structure, and oligomerization of caveolin: a building block of caveolae.  Curr Top Membr. 2015, 75, 305-336.

Rui H, Root KT, Lee J, Glover KJ, Im W, Probing the U-shaped Conformation of Caveolin-1 in a Bilayer.  Biophys J. 2014, 106, 1371-1380.

Rieth MD, Lee J, Glover KJ. Probing the Caveolin-1 P132L Mutant: Critical Insights into Its Oligomeric Behavior and Structure.  Biochemistry. 2012, 51, 3911-3918.

Lee J, Glover KJ. The transmembrane domain of caveolin-1 exhibits a helix-break-helix structure.  Biochim Biophys Acta. 2012, 1818, 1158-1164.

Mohanty P, Lee J, Glover KJ, Landskron K. Discoid Bicelles as Efficient Templates for Pillared Lamellar Periodic Mesoporous Silicas at pH 7 and Ultrafast Reaction Times. Nanoscale Res Lett. 2010, 6, 61.

Zhang J, Li D, Liu G, Glover KJ, Liu T. Lag Periods During the Self-Assembly of {Mo72Fe30} Macroions: Connection to the Virus Capsid Formation Process.  J Am Chem Soc. 2009, 131, 15152-15159.

Diefenderfer C, Lee J, Mlyanarski S, Guo Y, Glover KJ. Reliable expression and purification of highly insoluble transmembrane domains.  Anal Biochem. 2009, 384, 274-278.

Chen MM, Glover KJ, Imperiali B. From Peptide to Protein: Comparative Analysis of the Substrate Specificity of N-Linked Glycosylation in C. jejuni.  Biochemistry. 2007, 46, 5579-5585.