Steven L. Regen

Lehigh University Chemistry - Steven L. Regen
University Distinguished Professor
Sinclair Lab, Room 340B
(610) 758-4842

Research Interests:

Lipids and membranes, drug delivery, drug design, Langmuir-Blodgett films

Teaching Interests:

Lipids and membranes, organic chemistry, undergraduate research en masse

Selected Recent Publications:

Wang, Y.; Janout, V.; Regen, S. L. “Creating Poly(ethylene oxide)-Based Polyelectrolytes for Thin Film Construction Using an Ionic Linker Strategy, Chem. Mater., 22, 1285-1287 (2010).

Turkyilmax, S.; Mitomo, H.; Chen, W-H.; Regen, S. L. “Phospholipid Complexation of General Anesthetics in Fluid Bilayers,” Langmuir, 26, 5309-5311 (2010).

Janout, V.; Turkyilmax, S.; Wang, M.; Wang, Y.; Manaka, Y.; Regen, S. L. “An Upside Down View of Cholesterol’s Condensing Effect: Does Surface Occupancy Play a Role?”, Langmuir, 26, 5316-5318 (2010). Wang, M.; Janout, V.; Regen, S. L., “Glued Languir-Blodgett Bilayers From Calix[n]arenes: Influence of Calix[n]arene Size on Ionic Crosslinking, Film Thickness and Permeation Selectivity”, Langmuir, 26, 12988-12993 (2010).

Wang, M.; Janout, V.; Regen, S. L. “Hyper-thin Organic Membranes with Exceptional H2/CO2 Permeation Selectivity: Importance of Ionic Crosslinking and Self-Healing”, Chem. Comm., 47, 2387-2389 (2011).

Daly, T.; Wang, M.; Regen, S. L. “The Origin of Cholesterol’s Condensing Effect”, Langmuir, 27, 2159-2161 (2011).

Turkyilmaz, S.; Almeida, P. F.; Regen, S. L. “Effects of Isoflurane, Halothane and Chloroform on the Interactions and Lateral Organization of Lipids in the LiquidOrdered Phase”, Langmuir, 27, 14380-14385 (2011).

Cline, L. L.; Janout, V.; Fisher, M.; Juliano, R. L.; Regen, S. L. “A Molecular Umbrella Approach to the Intracellular Delivery of siRNA”, Bioconjugate Chem., 22, 2210-2216 (2011).

Wang, M.; Janout, V.; Regen, S. L. “Minimizing Defects in Polymer-Based Langmuir-Blodgett Monolayers and Bilayers Via Gluing”, Langmuir, 28, 4614-4617 (2012).

Janout, V.; Daly, T. A.; Cline, L. L.; Kulp, L. J.; Regen, S. L. “Stimulated Release of Cholesterol From Liposomal Membranes by a PEGylated Phospholipid”, Bioconjugate Chem. 23, 336-339 (2012).

Daly, T. A.; Almeida, P. F.; Regen, S. L., “Sorting of Lipidated Peptides in Fluid Bilayers: A Molecular-Level Investigation”, J. Am. Chem. Soc., 134, 17245-17252 (2012).

Chen, W. H.; Wennersten, C.; Moellering, R. C. Jr.; Regen, S. L. “Towards Squalamine Mimics: Synthesis and Antibacterial Activities of Head-to-Tail Dimeric Sterol-Polyamine Conjugates”, Chemistry and Biodiversity, 10, 385-393 (2013).

Wang, M.; Janout, V.; Regen, S. L., “Gas Transport Across Hyper-Thin Membranes, Acc. Chem. Res., 46, 2743-2754 (2013). 21 253. Wang, M.; Janout, V.; Regen, S. L. “Unexpected Barrier Properties of Structurally Matched and Unmatched Polyelectrolyte Multilayers”, Chem Commun., 49, 3576- 3578 (2013).

Wagner, K. C.; Wang, Y.; Regen, S. L.; Vezenov, D. V. “Yield Strength of Structurally Siminar Langmuir-Blodgett Films Determined by Friction Force Microscopy”, Phys. Chem. Chem. Phys., 15, 14037-14046 (2013).

Krause, M. R.; Turkyilmaz, S.; Regen, S. L. “Surface Occupancy Plays a Major Role in Cholesterol’s Condensing Effect”. Langmuir, 29, 10303-10306 (2013).

Wang, M.; Yi, S.; Janout; V.; Regen, S. L., “A 7 nm Thick Polymeric Membrane with H2/CO2 Selectivity of 200 That Reaches the Upper Bound”, Chem. Mater. 25, 3785-3787 (2013).

Lin, C.; Chen, Q.; Yi, S.; Wang, M.; Regen, S. L. “Polyelectrolyte Multilayers on PTMSP as Asymmetric Membranes for Gas Separations: Langmuir-Blodgett Versus Self-Assembly Methods”, Langmuir, 30, 687-691 (2014).

Janout, V.; Cline, L. L.; Feuston, B. P.; Klein, L.; O’Brien, A.; Tucker, T.; Yuan, Y.; O’Neill-Davis, L. A.; Peiffer, R. L.; Nerurkar, S. S.; Jadhav, V.; Tellers, D. M.; Regen, S. L. “Molecular Umbrella Conjugate for the Ocular Delivery of siRNA”, Bioconjugate Chem., 25, 197-201 (2014).

Krause, M. R.; Daly, T. A.; Almeida, P. F; Regen, S. L. “Push-Pull Mechanism For Lipid Raft Formation”, Langmuir., 30, 3285-3289 (2014).

Janout, V.; Bienvenu, C.; Schell, W.; Perfect, J. R.; Regen, S. L. “Molecular Umbrella-Amphotericin B Conjugates”, Bioconjugate Chem., 25, 1408-1411 (2014). 

Krause, M. R.; Wang, M.; Mydock-McGrane, L.; Covey. D. F.; Tejada, E.; Almeida, P. F.; Regen, S. L., “Eliminating the Roughness in Cholesterol’s β-Face: Does it Matter?”, Langmuir, 30, 12114--12118 (2014).

Krause, M. R.; Regen, S. L., “The Structural Role of Cholesterol in Cell Membranes: From Condensed Bilayers to Lipid Rafts”, Acc. Chem. Res., 47, 3512-3521 (2014).

Yi, S.; Lin, C.; Regen, S. L. “Splaying Hyperthin Polyelectrolyte Multilayers To Increase Their Gas Permeability”, Chem. Commun., 2014, DOE: 10.1039/C4CC08239G.

Wang, C.; Krause, M. R.; Regen, S.L., “Push and Pull Forces in Lipid Raft Formation: The Push Can Be As Important As the Pull”, J. Am. Chem. Soc., submitted