Graduate Courses

CHM 400 First Year Graduate Student Seminar.
First year graduate student seminar course and introduction to research.  Topics include: research opportunities in the department, introduction to instrumentation facilities, ethics in science, use of library facilities, effective teaching methods.
CHM 405 Organometallic Chemistry.  3 Credits
The chemistry of compounds containing carbon to metal bonds.  Among topics covered are the following: organic compounds of the representative elements from Group I to IV; the chemistry of ferrocene and related pi-bonded organometallic complexes; metal carbonyl and nitrosyl complexes; dioxygen and dinitrogen complexes; organic synthesis utilizing organometallic catalysts.
CHM 407 Advanced Inorganic Chemistry.  3 Credits
Introduction to transition metal complexes; theories of bonding; kinetics and mechanisms of transition metal complex reactions; selected aspects of organometallic chemistry; bio-inorganic chemistry.
Prerequisites: Must have completed one semester of physical chemistry and have College of Arts and Sciences graduate student status
CHM 421 Chemistry Research.  1-6 Credits
Research in one of the following fields of chemistry: analytical, inorganic, organic, physical, polymer or biochemistry.
CHM 423 Chemical Biology.  3 Credits
Chemical biology is a discipline at the interface of chemistry and biology. It entails the design, synthesis, and evaluation of probes, substrates, and materials for the study of biological systems using chemical principles. Chemical biology can take inspiration from living cells for the design and synthesis of novel molecules and materials for non-biological applications. The class is designed to be an introduction to chemical biology for upper-level undergraduates and graduate students.
CHM 424 Medicinal and Pharmaceutical Chemistry.  3 Credits
Principles of drug design, structure activity relationships in antibacterial, antimalarial, anti-inflammatory and psychoactive drugs; synthesis and modes of action of pharmacologically active agents radioactive pharmaceuticals.
Prerequisites: CHM 358
CHM 425 Pharmaceutical Regulatory Affairs 1: Drug Discovery to Approval.  3 Credits
Coverage includes the stages of the drug approval process and how these relate to the laboratory activities that provide the scientific basis of the New Drug Application (NDA).  Lectures treat drug discovery, chemical process development of the active pharmaceutical ingredient (API), and pharmaceutical process development of the drug product.  Regulatory issues in screening and testing, the management of the preclinical trials, and the management of clinical trials will be covered.
CHM 426 Statistical Thermodynamics.  3 Credits
Principles and applications of statistical mechanics to chemical problems.  A study of the techniques for evaluating the properties of matter in bulk from the properties of molecules and their interactions.
CHM 427 Thermodynamics & Kinetics. 3 Credits
Development of the principles of classical and statistical thermodynamics and their applications to chemical systems. In classical thermodynamics, emphasis will be on systems in which composition is of major concern: solutions, chemical and phase equilibria.  Kinetic theory of gases; chemical reaction kinetics.This course cannot be taken by students who have already taken CHM 342.
Prerequisite: Must have College of Arts and Sciences graduate student status
CHM 428 Pharmaceutical Regulatory Affairs-II-Biomarkers for Pharmaceutics and Diagnostics: Laws & Regulation.  3 Credits
For decades diagnostic products and technologies have been used to monitor or detect a variety of indicators for disease and infection. Each year, over 4,000 devices are reviewed by the U.S. Food & Drug Administration for safety and efficacy before being allowed to enter the marketplace. Today, regulations have set in motion the use of Biomarkers as a key element for new pharmaceutical development. Biomarkers in a way similar to Diagnostic markers will become a method to demonstrate safety and efficacy of experimental drugs during human trials. This course will review the history of Biomarker and medical device law and regulations in the United States. It will also define the current scientific requirements for Biomarkers to meet the new regulations. Case studies will be used to educate participants on the use of Biomarkers in pharmaceutical development as well as Design Controls, Quality System Regulations, Manufacturing Requirements for diagnostic testing technologies. Specific examples include Nucleic Acid Diagnostics, Cardiovascular Stents, Drug Delivery, Cancer Diagnostics, and Consumer Self-Testing. Students will also use knowledge gained to prepare class presentations to address current issues within the field. This course is one of four courses required to fulfill the requirements for a Certificate in Regulatory Affairs. It may be applied as a 400-level credit in the Masters of Chemistry degree program.
CHM 430 Chemical and Biochemical Separations.  3 Credits
Theory and applications of equilibrium and nonequilibrium separation techniques at both the analytical and preparative levels.  Solvent and buffer extractions, chromatographic separations (e.g., thin layer, partition, gas liquid, gel filtration, ion exchange, affinity, supercritical fluid), electrophoretic separations (e.g., gel, capillary, isoelectric focusing, immunoelectrophoresis), centrifugal separations (e.g., differential, velocity sedimentation, density gradient) and other separation methods (e.g., dialysis, ultrafiltration).  Examples will focus on biological applications.
CHM 431 Contemporary Topics in Analytical Chemistry.  1 Credit
Discussion of the current literature in analytical chemistry, including spectroscopy, separations, and electrochemistry. Students find current papers and lead discussions.
Repeat Status: Course may be repeated.
CHM 432 Chemometrics.  3 Credits
Mathematical and statistical methods for experimental design, calibration, signal resolution, and instrument control and optimization.
CHM 434 Advanced Topics in Spectroscopy.  3 Credits
Fundamentals of interactions of electromagnetic radiation with matter: electronic, vibrational, scattering based spectroscopies, instrumentation and signal processing.  Advanced applications to the analysis of molecular structure and chemical processes including surface analysis, time-resolved spectroscopies, and ultra sensitive spectroscopic techniques.
CHM 436 Special Topics in Analytical Chemistry.  1-3 Credits
Topics of contemporary interest in analytical chemistry.
Repeat Status: Course may be repeated
CHM 437 (BIOS 437) Pathophysiological Chemistry.  3 Credits
Biochemical basis of human diseases involving abnormal metabolism of proteins, nucleic acids, carbohydrates, and lipids. Emphasis on the correlation of the clinical presentation of disease processes seen as physiological dysfunctions with clinical laboratory methods.  Lectures, student presentations, and clinical case discussions.
Prerequisite: Must have completed one semester of biochemistry
CHM 438 Analytical Chemistry 3 Credits
Theory and practice of chemical analysis. Principles of quantitative separations and determinations; theory and application of selected optical and electrical instruments in analytical chemistry; interpretation of numerical data; design of experiments; solute distribution in separation methods.
Prerequisite: Must have College of Arts and Sciences graduate student status
CHM 442 Pharmaceutical Regulatory Affairs 3: Analytical Methods, Validation, and Data Manipulation.  3 Credits
A review of the FDA guidance and common industry practices. A presentation of the more user-friendly and higher accuracy analytical methods, which are supplanting traditional analysis.  Lectures will cover the eight fundamentals of analytical method validation: accuracy, linearity, precision, limits of detection, selectivity, limits of quantification, specificity, and ruggedness of method.  In addition, the student will be taught what to do when the results do not meet the Acceptance Criteria.  Lectures also cover evaluation of data streams for supporting conclusions.
CHM 443 (MAT 443) Solid-State Chemistry.  3 Credits
Crystal structure, diffraction in crystals and on surfaces, bonding and energy spectra in solids dielectrics, surface states and surface fields in crystals. 
Prerequisites: Must have completed one course in Linear Algebra and one course in Quantum Mechanics
CHM 444 Molecular Structure, Bonding and Dynamics.  3 Credits
Nature of chemical bonding as related to structure and properties of molecules and extended systems. Quantum chemistry of atoms and molecules applied to chemical transformations and spectroscopic transitions. Symmetry analysis and selections rules. Interpretation of electronic, vibrational and rotational spectra. 
Prerequisite:  Must have College of Arts and Sciences graduate student status
CHM 452 Advanced Organic Chemistry.  3 Credits
Reaction mechanism types and supporting physical chemical data. Classes of mechanisms include elimination, substitution, rearrangement, oxidation reduction, enolate alkylations, and others. 
Prerequisites:  Must have completed one year of Organic Chemistry and have College of Arts and Sciences graduate student status
CHM 453 Heterocyclic Compounds.  3 Credits
An intensive study of the syntheses, reactions and properties of heteroaromatic compounds including derivatives of thiophene, pyrrole, furan, indole, pyridine, quinoline, the azoles and the diazines all considered from the viewpoint of modern theories of structure and reaction mechanisms.
Prerequisites: CHM 358 or CHM 452
CHM 455 Organic Reactions.  3 Credits
Intensive survey of modern synthetic organic chemistry from a mechanistic standpoint. Classical Namereactions, olefin synthesis, organometallic reagents in synthesis, Woodward-Hoffmann rules, electrocyclic processes, enolate chemistry, and related reactions.
Prerequisites: CHM 358 or CHM 452
CHM 456 Spectral Analysis.  3 Credits
Use of data from nuclear magnetic resonance, infrared, ultraviolet, and mass spectrometric techniques for the determination of structure of organic compounds.  Emphasis on information from one- and two-dimensional proton and carbon NMR, and a mechanistic interpretation of data from mass spectrometry.
CHM 457 Organic Reaction Mechanisms.  3 Credits
Intensive in class problem solving that involves the formulation of reasonable reaction mechanisms for complex multi step pathways, i.e. organic transformations that proceed via highly energetic intermediates such as carbocations, carbanions, free radicals, carbenes, and nitrenes.
CHM 458 Topics in Organic Chemistry.  1-3 Credits
An intensive study of limited areas in organic chemistry.
Repeat Status: Course may be repeated.
CHM 462 Molecular Biophysics.  3 Credits
This course focuses on the physical tools that exist to obtain information about biological macromolecules, with an emphasis on spectroscopic and imaging techniques (e.g., circular dichroism, fluorescence spectroscopy, FRET, BRET, calorimetry, analytical ultracentrifugation, X-ray crystallography, electron microscopy, dynamic light scattering, surface plasmon resonance).  Lectures and discussion of research articles are used to illustrate the use of the different tools and methods.
CHM 463 Pharmaceutical Regulatory Affairs 4: Commercial Production, Validation, and Process Qualification.  3 Credits
This course covers the scientific principles and the registry requirements for polymeric implants, controlled-release drug depot units, pumps, point-of-care testing kits, contrast media for MRI, x-ray, and ultrasound and all FDA controlled products not defined as therapeutic pharmaceuticals.
CHM 465 Protein Separation & Biophysical Analysis.  3 Credits
Laboratory studies of techniques and principles used for the isolation, characterization, and biophysical analysis of proteins.
CHM 467 (BIOS 467) Principles of Nucleic Acid Structure.  3 Credits
An examination of the principles underlying nucleic acid structure including stereochemistry, electrostatics, hydration, torsional constraints, sequence specific effects, and interaction with nuclear proteins. Special emphasis will be placed on DNA structure. 
Prerequisites:  Must have completed one year of Biochemistry and Physical Chemistry or permission from the Department Chair
CHM 468 (BIOS 468) Principles of Protein Structure.  3 Credits
An examination of the principles underlying protein structure including stereochemistry, preferred tertiary structures, protein homology, excluded volume effects, time dependent structural fluctuations, and prediction of protein structure from sequence information. 
Prerequisites:  Must have completed one year of Biochemistry and Physical Chemistry or permission from the Department Chair
CHM 469 (BIOS 469) Biochemical Problem Solving I.  1 Credit
Applications of material covered in CHM 371 (BIOS 371) including techniques used in research.
CHM 470 (BIOS 470) Biochemical Problem Solving II.  1 Credit
Applications of concepts covered in CHM 372 (BIOS 372) including techniques used in research.
CHM 472 (BIOS 472) Lipids and Membranes.  3 Credits
Structure, physical properties and functions of lipids and their biological aggregates. Techniques for studying lipid assemblies, enzymes which act on lipids, membrane proteins and lipoproteins will also be discussed. Consent of department chair.
Prerequisites: CHM 372 or BIOS 372 or permission from the Department Chair
CHM 474 Pharmaceutical Regulatory Affairs 5: Pharmaceutics.  3 Credits
This course covers the development of therapeutic products subsequent to the initial discovery of the active pharmaceutical ingredient (API) through to the final dosage form. Both small molecule drugs and biotechnological pharmaceuticals will be included.  Issues of API formulation, choice of excipients, control of release, target specificity, mode of delivery, drug-drug interactions, and product stabilization will be addressed with special reference to the regulatory issues involved at that stage of drug development.  This course builds upon a foundation in organic, analytical, and biochemistry.
CHM 475 Advanced Topics in Chemistry.  1 Credit
Audiovisual courses in topics such as acid-base theory, NMR, chromatography, electroanalytical chemistry and mass-spectroscopy interpretation; course material obtained from the American Chemical Society.
Repeat Status: Course may be repeated
CHM 477 (BIOS 477) Topics In Biochemistry.  1-3 Credits
Selected areas of biochemistry, such as mechanisms of enzyme action, new developments in the chemistry of lipids, nucleic acids, carbohydrates and proteins. 
Prerequisite:  Must have completed one semester of Biochemistry
Repeat Status: Course may be repeated
CHM 479 (BIOS 479) Biochemical Techniques.  3 Credits
Laboratory studies of the techniques and principles involved in the isolation, identification, and biochemical transformation of carbohydrates, lipids, nucleic acids and proteins.
CHM 480 (BIOS 480) Advanced Biochemical Preparations.  1-3 Credits
An advanced laboratory course in the preparation, isolation, purification, and identification of biochemically produced materials. Emphasis is placed on materials and procedures of current interest in biochemistry.
Prerequisite: Must have completed two semesters of Biochemistry
CHM 481 Chemistry Seminar.  1-6 Credits
Student presentations on current research topics in the student’s discipline but not on subjects close to the thesis. A one-hour presentation and attendance at other presentations are required for credit.
Repeat Status: Course may be repeated
CHM 482 (CHE 482, MAT 482) Mechanical Behaviors of Polymers.  3 Credits
Mechanical behavior of polymers. Characterization of experimentally observed viscoelastic response of polymeric solids with the aid of mechanical model analogs.  Topics include time-temperature superposition, experimental characterization of large deformation and fracture processes, polymer adhesion, and the effects of fillers, plasticizer, moisture, and aging on mechanical behavior.
CHM 483 (CHE 483) Emulsion Polymers.  3 Credits
Fundamental concepts important in manufacture, characterization, and application of polymer latexes. Topics include colloidal stability, polymerization mechanisms and kinetics, reactor design, characterization of particle surfaces, latex rheology, morphology considerations, polymerization with functional groups, film formation and various application problems.
CHM 485 (CHE 485, MAT 485) Polymer Blends and Composites.  3 Credits
Synthesis, morphology, and mechanical behavior of polymer blends and composites. Mechanical blends block and graft copolymers, interpenetrating polymer networks, polymer impregnated solids and fiber and particulate-reinforce polymers are emphasized.
CHM 487 Topics in Colloid and Surface Chemistry.  3 Credits
Applications of colloid chemistry; special topics in surface chemistry. Lectures and seminar.
Repeat Status: Course may be repeated
CHM 488 Advanced Topics in Physical Chemistry.  1-3 Credits
Advanced topics in physical chemistry, such as photo chemistry and molecular beam dynamics, Fourier transform spectroscopy, kinetics of rapid reactions, theory of magnetic resonance, liquids and solutions.
Repeat Status: Course may be repeated
CHM 489 Organic Polymer Science II.  3 Credits
Continuation of CHM 394. Theory and mechanism of ionic vinyladdition chaingrowth polymerization.  Chain copolymerization by radical and ionic mechanism. Mechanism of ring-opening polymerization, stereochemistry of polymerization including ionic, coordination, and Ziegler-Natta mechanisms.  Reactions of polymers, including crosslinking, reaction of functional groups, graft and block copolymers, and polymer carriers and supports.
CHM 490 Thesis 1-6 Credits
Repeat Status: Course may be repeated
CHM 492 (CHE 492, MAT 492) Topics in Polymer Science.  3 Credits
Intensive study of topics selected from areas of current research interest such as morphology and mechanical behavior, thermodynamics and kinetics of crystallization, new analytical techniques, molecular weight distribution, non-Newtownian flow behavior, second-order transition phenomena, novel polymer structures.  Credit above three hours is granted only when different material is covered.
CHM 494 Quantum Chemistry.  3 Credits
Principles and applications of quantum mechanics to chemical problems.  Applications to chemical bonding, molecular structure, reactivity and spectroscopy.
CHM 499 Dissertation 1-15 Credits
Repeat Status: Course may be repeated.

Course Syllabi